I've stopped Sulfa as I was experiencing a bad taste & smell, which may be caused by sulfa. After a while it wasn't as effective and I too was prescribed methotrexate alongside. I'm about to start MTX & am hoping that I wont have side effects with that! The side effects of the methotrexate for me were horrendous (chronic chest infections) and I'm now asthmatic as a result. Hydroxychloroquine enhance or inhibit immune Aralen buy Hydroxychloroquine methotrexate sulfasalazine azathioprine lefludomide Sulfasalazine Azulfidine® is part of a class of medicines called sulfa drugs. It’s a mix of salicylate, which is the main ingredient in aspirin, and an antibiotic. Some people are allergic to all sulfa drugs, so they can’t take sulfasalazine Azulfidine®. Most people take two 500 mg tablets of sulfasalazine Azulfidine twice per day. Hi, I was diagnosed with RA and was put on sulfa, my rheumy tried adding mtx but i had awful side effects so am now on hydroxychloroquine and sulfa.this combination worked for anyone? just wondered how other people got on with it. May 28, 2016 I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. I had side effects from MTX, which largely wore off, but haven't had any problems with the Hydroxy or Sulpha. I refuse to take it now even if its my passport to biologic treatment. I started with MTX which worked, but not enough so the others were added in which has been better. Plaquenil and sulfasalazine Hydroxychloroquine sulfate and Sulfasalazine drug interaction., Combination hydroxychloroquine and sulfasalazine - do. Ra treatment plaquenil methotrexateHow long can you take plaquenil for ra Hydroxychloroquine sulfate Plaquenil is not a sulfa drug. That is a misconception. However, hydroxychloroquine can be associated with serious dermatological side effects including severe rashes and exacerbation of psoriasis. Plaquenil and Sulfa Allergies" Lupus Community - Support Group. Methotrexate, Plaquenil or Sulfasalazine Azulfidine.. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Drug interactions are reported among people who take Sulfasalazine and Plaquenil together. This study is created by eHealthMe based on reports of 7,132 people who take Sulfasalazine and Plaquenil from Food and Drug Administration FDA, and is updated regularly. eHealthMe has been monitoring drugs since 2008. DMARDs are Disease-Modifying Anti-Rheumatic Drugs used for a variety of conditions from Irritable Bowel Disease to scleroderma. DMARDs include immunosuppressants, antimalarial drugs, anti-inflammatory metals, and biologic agents. Immunosuppressants fall under a category of drugs referred to as DMARDs Disease-Modifying Anti-Rheumatic Drugs. Plaquenil is an arthritis medication and an anti infectious agent. Sulfasalazine is an arthritis medication and an IBD medication. There may be a negative interaction between Plaquenil and alcohol. There may be a negative interaction between Sulfasalazine and alcohol.