Plaquenil renal toxicity

Discussion in 'Canada Drugs Online' started by Nikon515, 11-Mar-2020.

  1. uLdesigner User

    Plaquenil renal toxicity


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    Jan 01, 2020 Renal clearance in rheumatoid arthritis RA patients taking Plaquenil for at least six months seemed to be similar to that of the single dose studies in volunteers, suggesting that no change occurs with chronic dosing. Range for renal clearance of unchanged drug was approximately 16 to 30%. Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. The risk of retinal toxicity was initially believed to be less than 1%. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1is now considered for new disease applications in diabetes, heart disease and adjunct.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Plaquenil renal toxicity

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  7. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin -containing structures in the body. With prolonged usage, metabolites in the drug accumulate in the retina. The drug remains in these parts even if the patients stopped taking the drugs.

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    Although it is not possible to predict which patients will develop retinal toxicity, high-risk characteristics include the following daily dose greater than 400 mg or, in people of short stature, a daily dosage over 6.5 mg/kg ideal body weight or total cumulative dose of more than 1,000 g. Sep 15, 2014 Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Aug 29, 2014 The Risk of Retinal Toxicity with Plaquenil. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases.

     
  8. birdmedia New Member

    13 mg/kg (10 mg/kg base), not to exceed 800 mg (620 mg base) followed by 6.5 mg/kg (5 mg/kg base), not to exceed 400 mg (310 mg base), at 6 hours, 24 hours and 48 hours after the initial dose. Effects of chloroquine on viral infections an old drug. PLAQUENIL hydroxychloroquine sulfate Label Plaquenil From Malaria Treatment to Managing Lupus, RA.
     
  9. Sergejus Well-Known Member

    Your doctor may diagnose morphea by examining the affected skin and asking you about your signs and symptoms. Difference Between a Lotion and a Cream LIST OF MEDICATIONS THAT MAY STAIN OR DAMAGE CLOTHING Hydroxychloroquine Uses, Dosage & Side Effects -
     
  10. vitas Moderator

    Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.

    Plaquenil - FDA prescribing information, side effects and uses
     
  11. submit Moderator

    Malaria Mode of action of chloroquine and mechanism of. Chloroquine Nivaquine® was widely used as antimalarial drug and saved many lives for decades. But, the effectiveness of chloroquine against Plasmodium falciparum has declined as resistant strains.

    Drug Resistance in the Malaria-Endemic World - CDC