In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Plaquenil and foul smelling urine How many people survived malaria with chloroquine Surgical chloroquine prep The imputability of hydroxychloroquine in the genesis of this discoloration is difficult to establish. Our study supports the hypothesis that ecchymosis, platelet antiaggregants and oral anticoagulants may be the main predisposing factors to hydroxychloroquine-induced pigmentation. Home August 2013 - Volume 19 - Issue 5 Hydroxychloroquine-Induced Hyperpigmentation. Log in to view full text. If you're not a subscriber, you can You can read the full text of this article if you-- Select an option -- Log In Buy This Article Become a Subscriber An elderly woman presented with 6 months history of skin coloured to erythematous papules in annular pattern over extremities, upper back and neck. The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B. Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine induced pigmentation Hydroxychloroquine-Induced Hyperpigmentation, Hydroxychloroquine-Induced Hyperpigmentation JCR. Sd-oct and plaquenil toxicityMethotrexate hydroxychloroquine sulfasalazineDoes plaquenil help discoid lupus The incidence of hydroxychloroquine-related hyperpigmentation in patients with systemic lupus erythematosus is about 7%, but unlike hydroxychloroquine-related retinopathy, there is no clear association with cumulative dose or duration of use.1 Roughly half of cases occur in the first five years of treatment. Hydroxychloroquine-related skin discoloration CMAJ. Hydroxychloroquine induced cutaneous pigmentation a unique.. Persistent cutaneous hyperpigmentation due to.. Antimalarial drug–induced oral hyperpigmentation is uncommon and is reported to occur on the hard palate, gingiva, lips, and buccal mucosa.15, 47 In a retrospective study, pigmentation of the buccal mucosa or the hard palate was seen in 10 patients 5% using chloroquine, but none in hydroxychloroquine, 50 and there are rare case reports of. Demonstrated that hydroxychloroquine-induced pigmentation is not rare. The imputability of hydroxychloroquine in the genesis of this discoloration is difficult to establish. Our study supports the hypothesis that ecchymosis, platelet antiaggregants and oral anticoagulants may be the main predisposing factors to hydroxychloroquine-induced. What is drug-induced skin pigmentation. Drug-induced skin pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti-inflammatory drugs NSAIDs, phenytoin, antimalarials, amiodarone, antipsychotic drugs, cytotoxic drugs, tetracyclines, and heavy metals.