What is putative chloroquine transporter

Discussion in 'Canadian Drugs' started by Love_Britney, 08-Mar-2020.

  1. MapcuaHuH New Member

    What is putative chloroquine transporter


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Analysis of the D. dadantii genome revealed the presence of a putative ABC transporter, YbiT, which may be important in intermicrobial competition. The protein YbiT showed identity with those of other Gram-negative bacteria including E. coli 87%, Vibrio cholerae N16961 74%, P. aeruginosa PA01 72%, and Neisseria meningitidis MD58 63%. The Chloroquine Resistance Transporter PfCRT was originally identified because mutations in this protein confer chloroquine resistance in the human malaria parasite, Plasmodium falciparum. However, the mechanism by which they do so has been the subject of ongoing debate. Martin et al. p. Chloroquine is structurally related to quinine and quinidine, and cardiotoxicity resulting from any of these brokers could be indistinguishable. is the drug of alternative within the few malaria-endemic areas free of CRPf. Combining chloroquine and proguanil is an option for CRPf when different first-line antimalarials are contraindicated.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    What is putative chloroquine transporter

    Chloroquine-resistance transporter – NIH Director's Blog, Chloroquine Transport via the Malaria Parasite’s.

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    Mar 17, 2020 Don’t breastfeed while taking this drug with out first talking to your healthcare provider. The Food and Drug Administration FDA first approved chloroquine in 1949. The compound has weak intrinsic antimalarial exercise and may act as a aggressive inhibitor of the binding of chloroquine to the putative transporter. May regulate endogenous transporter. UniProtKB. x; UniProtKB. Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents. Plasmodium falciparum chloroquine resistance transporter Pfcrt gene at codon 76 and multidrug resistance gene 1 Pfmdr1 at codon 86 were investigated among 406 children with uncomplicated malaria presenting at five sentinel health centres in Ghana.

     
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