Chloroquine dose in pregnancy

Discussion in 'Canadian Ed Drugstore' started by Artsite, 06-Mar-2020.

  1. Jeremy11 Guest

    Chloroquine dose in pregnancy


    Falciparum resistance is reported, especially in persons likely to have acquired a significant degree of immunity, and also wherever P. Chloroquine is a 4-aminoquinoline which has marked, rapid schizontocidal activity against blood forms of P. Adults, including pregnant women, and children: Total dose: 25 mg/kg given over 3 days. Treatment Oral administration To avoid nausea and vomiting chloroquine should be administered after meals.

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    Chloroquine crosses the placenta and is also found in low levels in breast milk, so pregnancy and lactation are often listed as contraindications to its use see DermNet NZ’s pages on Safety of medicines taken during pregnancy and on Lactation and the skin. However, effects on the fetus and baby have been rarely reported and chloroquine has. R. S. Chandra, J. Orazem, D. Ubben, S. Duparc, J. Robbins, P. VandenbrouckeCreative solutions to extraordinary challenges in clinical trials methodology of a phase III trial of azithromycin and chloroquine fixed-dose combination in pregnant women in Africa For treatment of acute attacks of malaria in adults, one dose is usually taken right away, followed by half the dose 6 to 8 hours later and then half the dose once a day for the next 2 days. For prevention and treatment of malaria in infants and children, the amount of chloroquine phosphate is based on the child's weight.

    Chloroquine is also used for prophylaxis for pregnant women and non-immune individuals at risk. Dosage and administration All dosages are described in terms of the base.

    Chloroquine dose in pregnancy

    Chloroquine - Wikipedia, Dose Optimization of Chloroquine by Pharmacokinetic Modeling.

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  4. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for CHLOROQUINE.

    • CHLOROQUINE Drug BNF content published by NICE.
    • Chloroquine MedlinePlus Drug Information.
    • Aralen Chloroquine Uses, Dosage, Side Effects..

    Use in pregnancy. There is no evidence that chloroquine is harmful in prophylactic doses during pregnancy. Because of the susceptibility of pregnant women to falciparum malaria, it should be used at the recommended dosage for both prophylaxis and treatment wherever chloroquine-sensitive malaria is prevalent. Adverse effects Pregnant females in non-endemic areas should be advised not to travel to endemic areas or use appropriate prophylaxis. Pregnant females with uncomplicated malaria caused by chloroquine-sensitive P. vivax or P. ovale should be treated with chloroquine. Infected pregnant women should continue prophylaxis until delivery. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving chloroquine. Breastfeeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.

     
  5. GP1 Moderator

    400-600 mg (310-465 mg base) PO daily for 4-12 weeks; maintenance: 200-400 mg (155-310 mg base) PO daily With prolonged therapy, obtain CBCs periodically 400 mg (310 mg base) PO once or twice daily; maintenance: 200-400 mg (155-310 mg base) PO daily With prolonged therapy, obtain CBCs periodically 100-200 mg (77.5-155 mg base) PO 2-3 times/wk Take with food or milk Nausea, vomiting Headache Dizziness Irritability Muscle weakness Aplastic anemia Leukopenia Thrombocytopenia Corneal changes or deposits (visual disturbances, blurred vision, photophobia; reversible on discontinuance) Retinal damage with long-term use Bleaching of hair Alopecia Pruritus Skin and musculoskeletal pigmentation changes Weight loss, anorexia Cardiomyopathy (rare) Hemolysis (individuals with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency) Prolongs QT interval Ventricular arrhythmias and torsade de pointes Vertigo Tinnitus Nystagmus Nerve deafness Deafness Irreversible retinopathy with retinal pigmentation changes (bull’s eye appearance) Visual field defects (paracentral scotomas) Visual disturbances (visual acuity) Maculopathies (macular degeneration) Decreased dark adaptation Color vision abnormalities Corneal changes (edema and opacities) Abdominal pain Fatigue Liver function tests abnormal Hepatic failure acute Urticaria Angioedema Bronchospasm Decreased appetite Hypoglycemia Porphyria Weight decreased Sensorimotor disorder Skeletal muscle myopathy or neuromyopathy Headache Dizziness Seizure Ataxia Extrapyramidal disorders such as dystonia Dyskinesia Tremor Rash Pruritus Pigmentation disorders in skin and mucous membranes Hair color changes Alopecia Dermatitis bullous eruptions including erythema multiforme Stevens-Johnson syndrome Toxic epidermal necrolysis Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) Photosensitivity Dermatitis exfoliative Acute generalized exanthematous pustulosis (AGEP); AGEP has to be distinguished from psoriasis; hydroxychloroquine may precipitate attacks of psoriasis Pyrexia Hyperleukocytosis Hypersensitivity to 4-aminoquinoline derivatives Retinal or visual field changes due to 4-aminoquinoline compounds Long-term therapy in children Not effective against chloroquine-resistant strains of P. Individual plans may vary and formulary information changes. Hydroxychloroquine Oral Tablet 200Mg Drug Medication Dosage Information Hydroxychloroquine SULFATE - Hydroxychloroquine sulfate -
     
  6. ky4er New Member

    Hydroxychloroquine Sulfate Anxiety Reports - DrugInformer Side Effects Panic attacks, anxiety, rapid heartbeat, difficulty breathing, feeling like I am on speed. Generally not feeling well but have an over excess of energy. Generally not feeling well but have an over excess of energy.

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