Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Plaquenil dosage Hydroxychloroquine with vit d Technical Service Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others. Chloroquine diphosphate is an antimalarial and anti-inflammatory drug widely used to treat malaria and rheumatoid arthritis. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors TLRs. The solubilities of chloroquine diphosphate and 4,7-dichloroquinoline in water, ethanol, tetrahydrofuran, acetone, and acetonitrile were measured over the temperature range of 298.2 to 333.2 K. The solubilities of both analytes in different solvents increase smoothly with temperature. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine solubility Hydroxychloroquine - Wikipedia, Chloroquine diphosphate Autophagy Inhibitor MedChemExpress Drug reaction with acyclovir and sucralfate and hydroxychloroquine Chloroquine CAS NO.54-05-7 is stability stable, but light sensitive. It is incompatible with strong oxidizing agents. It is soluble in water, insoluble in alcohol, chloroform and ether. Chloroquine supplier CasNO.54-05-7. Solubility of Chloroquine Diphosphate and 4,7.. Hydroxychloroquine C18H26ClN3O - PubChem. Chloroquine phosphate is supplied as a crystalline solid. Aqueous solutions of chloroquine phosphate can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of chloroquine phosphate in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin. SAR OF CHLOROQUINE. Addition of –CH3 group at position #2 will reduce the activity as in santoquine. Addition of –CH3 group at position #8 will reduce the activity / totally loss the activity. Introduction of any other groups into the quinoline nucleus will reduce the activity.