Chloroquine in cancer therapy a double edged sword of autophagy

Discussion in 'Canadian Pharmaceuticals Online' started by interbadru, 15-Mar-2020.

  1. andr_chtts New Member

    Chloroquine in cancer therapy a double edged sword of autophagy


    Detailed information on how Wiley uses cookies can be found in our Privacy Policy. Thank you for your interest in spreading the word about Science.

    Plaquenil long term us Gi problems with hydroxychloroquine How long chloroquine tablets is good afternoon Plaquenil for thromboembolism

    The emerging role of autophagy in cancer is one of a double-edged sword. On the one hand, autophagy enables tumor cells to tolerate stress including a hypoxic microenvironment, starvation, and probably some forms of therapy. Inhibition of autophagy may allow the continuous growth of precancerous cells, and autophagy can act as a suppressor of cancer 10, 11. Later, as a tumor grows, cancer cells may need autophagy to survive nutrient-limiting and low-oxygen conditions, especially in the internal region of the tumor that is poorly vascularized 12. Jan 01, 2013 Chloroquine in cancer therapy a double-edged sword of autophagy. Kimura T1, Takabatake Y, Takahashi A, Isaka Y. Author information 1Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.

    We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.

    Chloroquine in cancer therapy a double edged sword of autophagy

    Autophagy—A doubleedged sword in oncology - Apel - 2009., Autophagy in Health and Disease A Double-Edged Sword

  2. Log p chloroquine
  3. What is plaquenil for
  4. Hydroxychloroquine vs plaquenil
  5. Hydroxychloroquine methotrexate price
  6. It is like a double-edged sword that can play either a protective or destructive role in cancer, by pro-survival. chloroquine, etc. are reported in pre-clinical and clinical study. in cancer therapy. Keywords Autophagy, cancer, ATG, ULK inhibitor, Vps34 inhibitor, mammalian target of rapamycin inhibitors.

    • Targeting autophagy with small molecules for cancer therapy.
    • Chloroquine in cancer therapy a double-edged sword of autophagy..
    • Crosstalk between autophagy and epithelial. - Molecular Cancer.

    Negative effects of autophagy; Cancer. the lysosomotropic agent chloroquine induces a myopathy in cultured cells and rats similar to that of a human disorder termed distal myopathy with rimmed vacuoles, as well as inclusion body myositis. A Double-Edged Sword. By Takahiro Shintani, Daniel J. Klionsky. Science 990-995. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Correction Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy Cancer Res February 15 2013 73 4 1446; DOI 10.1158/0008-5472. CAN-13-0041 Share This Article Copy

     
  7. KATYA-PERM Moderator

    In some cases, they may not be available in every strength or form as the brand-name drug. Shifting from Prednisone to Hydroxychloroquine Mayo Clinic. Plaquenil and Prednisone Plaquenil vs. Prednisone Prescription Treatment for.
     
  8. oxybuterat Guest

    Aralen Chloroquine Uses, Dosage, Side Effects, Interactions, Warning This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days. The dosage for adults of low body weight and for infants and children should be determined as follows First dose 10 mg base per kg but not exceeding a single dose of 600 mg base.

    Aralen chloroquine Malaria Drug Side Effects & Dosage