Chloroquine in cancer therapy a double edged sword of autophagy

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  1. andr_chtts New Member

    Chloroquine in cancer therapy a double edged sword of autophagy

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    The emerging role of autophagy in cancer is one of a double-edged sword. On the one hand, autophagy enables tumor cells to tolerate stress including a hypoxic microenvironment, starvation, and probably some forms of therapy. Inhibition of autophagy may allow the continuous growth of precancerous cells, and autophagy can act as a suppressor of cancer 10, 11. Later, as a tumor grows, cancer cells may need autophagy to survive nutrient-limiting and low-oxygen conditions, especially in the internal region of the tumor that is poorly vascularized 12. Jan 01, 2013 Chloroquine in cancer therapy a double-edged sword of autophagy. Kimura T1, Takabatake Y, Takahashi A, Isaka Y. Author information 1Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.

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    Chloroquine in cancer therapy a double edged sword of autophagy

    Autophagy—A doubleedged sword in oncology - Apel - 2009., Autophagy in Health and Disease A Double-Edged Sword

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  6. It is like a double-edged sword that can play either a protective or destructive role in cancer, by pro-survival. chloroquine, etc. are reported in pre-clinical and clinical study. in cancer therapy. Keywords Autophagy, cancer, ATG, ULK inhibitor, Vps34 inhibitor, mammalian target of rapamycin inhibitors.

    • Targeting autophagy with small molecules for cancer therapy.
    • Chloroquine in cancer therapy a double-edged sword of autophagy..
    • Crosstalk between autophagy and epithelial. - Molecular Cancer.

    Negative effects of autophagy; Cancer. the lysosomotropic agent chloroquine induces a myopathy in cultured cells and rats similar to that of a human disorder termed distal myopathy with rimmed vacuoles, as well as inclusion body myositis. A Double-Edged Sword. By Takahiro Shintani, Daniel J. Klionsky. Science 990-995. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Correction Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy Cancer Res February 15 2013 73 4 1446; DOI 10.1158/0008-5472. CAN-13-0041 Share This Article Copy

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    In some cases, they may not be available in every strength or form as the brand-name drug. Shifting from Prednisone to Hydroxychloroquine Mayo Clinic. Plaquenil and Prednisone Plaquenil vs. Prednisone Prescription Treatment for.
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    Aralen Chloroquine Uses, Dosage, Side Effects, Interactions, Warning This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days. The dosage for adults of low body weight and for infants and children should be determined as follows First dose 10 mg base per kg but not exceeding a single dose of 600 mg base.

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