Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil and edema Plaquenil and cancer risk A retrovirus is a virus whose genes are encoded in RNA, and, using an enzyme called reverse transcriptase, replicates itself by first reverse-coding its genes into the DNA of the cells it infects. Like other viruses, retroviruses need to use the cellular machinery of the organisms they infect to make copies of themselves. Based on previous studies done on retrovirus caused mouse mammary adenocarcinoma, it is suggested that a treatment regimen with 6-propylthiouracil, chloroquine phosphate and 5-fluorouracil which resulted in 77% and 65% complete mouse tumor remission, may be effective in treating AIDS and other retrovirus-caused diseases. Chloroquine has a broad spectrum anti-viral effect. Before now, there have been numerous HIV-drug trials involving chloroquine and its derivative, hydroxychloroquine. It has been discovered that they are able to inhibit glycosylation of viral receptors and induce production of non-infectious retrovirus particles in HIV-1. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine retrovirus production Production -, Treatment for AIDS and other retrovirus-caused diseases. Why is plaquenil prescribed for lupusHydroxychloroquine eliminationHydroxychloroquine induced pigmentationDoes plaquenil lower platelets As a result, viral infectivity is impaired. Finally, chloroquine induces the production of non-infectious retrovirus particles, as shown with the avian reticuloendotheliosis virus REV-A and with HIV-1. Effects of chloroquine on viral infections an old drug.. Coronavirus How Chloroquine and Other Antivirals Inhibit the Virus. Blocking Type I Interferon Production A New Therapeutic.. A retrovirus is a type of RNA virus that inserts a copy of its genome into the DNA of a host cell that it invades, thus changing the genome of that cell. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro backwards. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Appropriate NIH and other regional guidelines should be followed in the use of these recombinant retrovirus production systems. The user is strongly advised NOT to create retroviruses capable of expressing known oncogenes in amphotropic or polytropic host range viruses.