Pigmentation can be either normal or abnormal discoloration of oral mucous membrane. The purpose of this review mainly focuses on the main oral pigmented lesions, in order to help the clinicians establish a better approach towards the patients with pigmented oral lesions and to provide thorough knowledge regarding such lesions for patient reassurance, early definitive diagnosis and prompt treatment. Expired chloroquine still good Hydroxychloroquine does this drug treat gout Treated with primaquine and chloroquine How does chloroquine phosphate work malaria Given the history of long-term chloroquine use, the top clinical working diagnosis was drug-induced oral pigmentation caused by chloroquine phosphate. To confirm this, and rule out the possibility of melanoma, a surgical evaluation was requested and the patient then underwent an incisional biopsy Fig. 2. The pigmentation resolved in two patients following chloroquine withdrawal despite being substituted by hydroxychloroquine. Hence, hydroxychloroquine may score over chloroquine not only with reference to ocular toxicity 9, but also with reference to cutaneous toxic-ity, for its long term use in patients suffering from con- Quizzn is a young service that bears only one goal - to make the learning process as enjoyable, social, and easy as possible. It is a free application that has the ability to connect people that are eager to learn, share knowledge and just have fun. Pigmented lesions affecting the skin were not included in our review. Relevant data concerning oral pigmented lesions, clinical features and the possibility of malignant transformation of such lesions were reviewed thoroughly from pubmed literature published in English. Chloroquine oral pigmentation Hard palate hyperpigmentation secondary to chronic., Hyperpigmentation of the Skin Following Chloroquine Treatment. Hydroxychloroquine blood monitoringHydroxychloroquine and dormancyAre you more likely to get sick while take hydroxychloroquineHydroxychloroquine sulfate hcqChloroquine autophagy sigma Oral pigmentation is a relatively common condition that may involve any portion of the oral cavity. Multiple causes are known, and they may range from simple iatrogenic mechanisms, such as implantation of dental amalgam, to complex medical disorders, such as Peutz-Jeghers syndrome. Disorders of Oral Pigmentation Background, Pathophysiology, Etiology. Which of the following has been implicated in the development.. Drug-Induced Pigmentation Background, Pathophysiology, Etiology. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Pigmentation varies, depending on the causative drug. It can involve accumulation of melanin, deposits of the drug or one of its metabolites, synthesis of pigments under the inﬂuence of the drug or deposition of iron after damage to the dermal vessels.11 Chloroquine and other quinine derivatives are used Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided.