The most common side effect associated with its use is retinal toxicity, which may be irreversible. Therefore, it is pertinent to know the findings, risk factors, and screening tests necessary to prevent retinal damage. Chloroquine phosphate cost Is plaquenil toxic to the liver How safe is chloroquine during pregnancy The reader's question and comment prompted me to do a little more research on the question of whether plaquenil toxicity was reversible which led me to the results of this study, which was published in JAMA Opthamology Jan 2011-- the same month and year as the Sjogren's Syndrome Foundation article was published. The study authors concluded "Sustained visual improvement following cessation of drug therapy was not observed in any patient in this series, and our identification of 6 patients. Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible. Jan 18, 2019 Hydroxychloroquine Plaquenil was originally used to treat malaria and is now used mostly to treat rheumatological and dermatological diseases. Its most frequent use now is for Rheumatoid Arthritis RA and Lupus and is often very effective in mitigating the joint and arthritic symptoms these diseases can cause. During the first five years of use, the rate of toxicity was found to be 0.7%, rising significantly to more than 1% after five to seven years of use. The prevalence of retinal toxicity has varied among different studies. Is plaquenil retinal toxicity reversible Plaquenil Side Effects Common, Severe, Long Term -, Rx Side Effects New Plaquenil Guidelines and More - American. How does chloroquine work in the bodyLow-dose hydroxychloroquine in treatment of porphyria Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine-Induced Retinal Toxicity - American.. What can Hydroxychloroquine Plaquenil do to my eyes?. Has anyone experienced plaquenil toxicity with damage to eyes?. Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. This condition does not cause symptoms and is reversible with cessation of the medication. The finding of corneal verticillata bares no correlation with retinal toxicity and is not an indication to stop the medication. The hallmark of hydroxychloroquine toxicity is bilateral pigmentary retinopathy. Patients with early retinal findings are often asymptomatic despite having subtle paracentral scotomas. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug.