Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Sulfasalazine and hydroxychloroquine Chloroquine effective against malaria Plaquenil appetite loss The main outcomes were toxicity as determined by characteristic visual field loss or retinal thinning and photoreceptor damage. They also examined risk factors and prevalence. The study findings revealed that when hydroxychloroquine was used at doses 5mg /kg, the risk of retinopathy was 1% in the first 5 yrs. 2% in 10 yrs. 20 % after 20 yrs. Apr 20, 2011 Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3 The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Macular thinning and plaquenil Hydroxychloroquine Plaquenil Toxicity and Recommendations., New Plaquenil Guidelines Plaquenil et piluleOff label plaquenilPlaquenil retinal octChloroquine trade name Focus on Eyes Long-term Plaquenil intake can affect your vision. Taking high doses or long-term treatment of Plaquenil, an anti-malaria drug used to treat lupus, can lead to vision problems. Focus on Eyes Long-term Plaquenil intake can affect your.. Hydroxychloroquine Plaquenil. Selective Thinning of the Perifoveal Inner Retina as an Early.. Mar 17, 2017 Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes. The presentation goes over how to spot and what testing to perform to make sure there is no retinal toxicity. The retinal ganglion cells are densest in the macula and form a stratified multi-cellular layer within the central 6 degrees of visual field. Therefore, loss of axons and the corresponding soma in this location is likely to cause a thinning of the retinal ganglion cell layer. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. macular disease, retinal or visual.