It is not clear whether this advantage is still present when primaquine is given to achieve a complete cure. Compared to alternative ACTs People who are treated with dihydroartemisinin-piperaquine are probably less likely to have another episode of . Hydroxychloroquine and stomach pain Chloroquine iupac name Plaquenil and general anesthesia Hydroxychloroquine blindnesd The concept of combination therapy is based on the synergistic or additive potential of two or more drugs, to improve therapeutic efficacy and also delay the development of resistance to the individual components of the combination. Artemisinin based combinations are known to improve cure rates, reduce the development of resistance and they. Artemisinin and its semisynthetic derivatives are a group of drugs used against malaria due to Plasmodium falciparum. It was discovered in 1972 by Tu Youyou, who was co-recipient of the 2015 Nobel Prize in Medicine for her discovery. Treatments containing an artemisinin derivative are now standard treatment worldwide for P. falciparum malaria. Artemisinin is isolated from the plant Artemisia annua, sweet wormwood, a herb employed in Chinese traditional medicine. A precursor compound can be produ Malaria is a major public health problem in endemic countries including Sudan, where about 75% of populations are at risk. Due to widespread of chloroquine-resistant strains of Plasmodium falciparum, artemisinin-based combination therapy ACT is currently treatment of choice for malaria in the vast majority of malaria-endemic countries. This systematic review and meta-analysis is performed to. This advantage may be present even when additional primaquine is given to achieve a complete cure. In areas where chloroquine no longer cures the infection, ACTs offer an effective alternative. Vivax malaria during the next six weeks than those treated with alternative ACTs (only artemether-lumefantrine, artesunate plus sulphadoxine-pyrimethamine and artesunate plus amodiaquine have been compared). Even in areas where chloroquine remains effective, this finding may allow for simplified protocols for treating all forms of malaria with ACTs. Artemisinin-based combination therapy chloroquine Antimalarial Drug Resistance, Artemisinin-based Combination., Artemisinin - Wikipedia Tumors associated with plaquenil Plasmodium falciparum resistance to chloroquine and sulphadoxine–pyrimethamine has led to the recent adoption of artemisinin-based combination therapies ACTs as the first line of treatment against malaria. ACTs comprise semisynthetic artemisinin derivatives paired with distinct chemical classes of longer acting drugs. Artemisinin-based combination therapies a vital tool in.. Efficacy and safety of artemisinin-based combination.. Artemisinin-based combination therapy ACT MalariaWorld. Artemisinin's derivatives artemether, artesunate, and dihydroartemisinin are discussed as to their properties and in different formulations and in combination with Chinese discovered chemical antimalarials, lumefantrine and naphthoquine and with another chemical piperaquine; an artemisinin-based combination therapy concept to increase efficacy, shorten treatment course, and prevent resistance developing. Chloroquine is no longer efficacious in most of the world. The first line option for treatment of P. falciparum is now artemisinin based co mbination therapy, such as artemether-lumefantrine. In Guinea-Bissau, in contrast to the rest of Africa, chloroquine has been considered to be eff ective by practitioners in line with clinical Recently, WHO proposed modifications of endemic countries guidelines, changing from monotherapy to artemisinin-based combination therapy ACT. In view of this, and after a scientific consensus meeting held in January 2004, the National Malaria Control Programme of Cameroon announced that amodiaquine will be replaced by the combination.