Chloroquin function in lysosome

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  1. leva New Member

    Chloroquin function in lysosome


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Accumulation of chloroquine in the lysosome inhibits phospholipase A2. It has recently been shown that antagonists of cytoplasmic phospholipase A2 inhibit multiple endocytic pathways 42. In this case, chloroquine could be maintaining BMPR-II at the cell surface via another mechanism other than lysosomal inhibition. Uses of Chloroquine It is used to treat or prevent malaria. It is used to treat a type of bowel infection. It may be given to you for other reasons. ADVERTISEMENTS Some of the main functions of Lysosomes are as follows 1. Intracellular digestion The word lysosome is derived from lyso lytic or digestive; and soma body thus helping in digestion. Pinocytic vacuoles formed as a result of absorption of fluid substance into cell or phagocytic vacuoles formed by absorption of solid particles into cell,

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Chloroquin function in lysosome

    Lysosomal Function and Dysfunction Mechanism and Disease, Chloroquine Indications, Side Effects, Warnings -

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  6. Aug 24, 2017 Chloroquine CQ or its derivative hydroxychloroquine HCQ has been widely tested in preclinical cancer models as an inhibitor of the autophagy–lysosomal pathway. These antimalarial drugs have.

    • Lysosomotropism depends on glucose a chloroquine resistance..
    • Main Functions of Lysosomes Biology.
    • Lysosome Definition, Structure & Function Sciencing.

    Chloroquine CQ, one of the lysosomotropic agents, has an immunosuppressive effect and is used for the treatment for rheumatoid arthritis RA and systemic lupus erythematosus SLE. Nov 25, 2019 Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine is used to treat and to prevent malaria. One study has identified palmitoyl-protein thioesterase 1 PPT1, an enzyme involved in the catabolism of lipid-modified proteins, as a potential lysosomal target of chloroquine and chloroquine.

     
  7. nicant Well-Known Member

    Applies to chloroquine: oral tablet Along with its needed effects, chloroquine may cause some unwanted effects. Chloroquine MedlinePlus Drug Information Chloroquine Alternatives & Similar Drugs - Chloroquine Indications, Side Effects, Warnings -
     
  8. SonarDima XenForo Moderator

    Volume of distribution - LinkedIn SlideShare Water Soluble drugs have low Vd. Eg. Gentamycin vd = 110 ml/kg 5. Lipid soluble drugs have high Vd Eg. Thiopental vd = 2300 ml/kg 6. Pathological condition. In edematous condition, water soluble drugs have high volume of distribution  8. Tissue binding. High Vd with higher tissue binding Eg.

    Chloroquine phosphate C18H32ClN3O8P2 - PubChem