According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance. How expensive is plaquenil per pill Why chloroquine Is plaquenil safe for pregnancy Drug interactions. What are the potential side. effects of chloroquine? Chloroquine is a relatively well-tolerated. medicine. The most common adverse reactions reported are stomach pain, nausea, vomiting, and headache. These side effects can often be lessened by taking chloroquine with food. Chloroquine may also cause itching in some people. Apr 02, 2019 Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Chloroquine CQ, 2 was developed as a result of intense antimalarial drug development efforts in the USA during World War II, but the compound was familiar to Germans as early as 1934 under the name resochin. 176 The safety, efficacy, and low cost brought chloroquine to the front lines to treat malaria, and it was used extensively for almost. These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine). Chloroquine class of drug Chloroquine C18H26ClN3 - PubChem, Aralen Chloroquine Uses, Dosage, Side Effects. Plaquenil testing aaoChloroquine dose in pregnancyHow long does it take for plaquenil to workLog p chloroquine Chloroquine Interactions. Antacids, such as Tagamet cimetidine and others. Arsenic trioxide. Rheumatrex, Trexall methotrexate Tylenol acetaminophen Iron products. Kaolin. Niacin. Rifadin or Rimactane rifampin Nydrazid isoniazid Medication for irregular heartbeat. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs. Chloroquine - an overview ScienceDirect Topics. Chloroquine Dosage Guide with Precautions -. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus. Chloroquine is not associated with serum enzyme elevations and is an extremely rare cause of clinically apparent acute liver injury. Chloroquine Oral tablet drug summary. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin chloroquine and Sontochin 3-methyl-chloroquine. These compounds belonged to a new class of antimalarials, the four-amino quinolines. The German research went no further and the formula for Resochin was passed to a US sister company.