It is an electrical disturbance which can be seen on an electrocardiogram (ECG). Excessive QT prolongation can trigger tachycardias such as Torsades de Pointes (Td P). I c hydroxychloroquine hsdd Icd 10 code long term use of plaquenil Pct and hydroxychloroquine Chloroquine should be used with caution in patients with cardiac disease, a history of ventricular arrhythmias, uncorrected hypokalemia and/or hypomagnesemia, or bradycardia 50 bpm, and during concomitant administration with QT interval prolonging agents due to potential for QT interval prolongation see WARNINGS, PRECAUTIONS, Drug. Before using chloroquine, tell your doctor or pharmacist if you have any of the following conditions certain heart problems heart failure, slow heartbeat, QT prolongation in the EKG, family history of certain heart problems QT prolongation in the EKG, sudden cardiac death. Although it isn't mentioned specifically, I believe QT prolongation is the main cause of death in several other suicide methods, such as chloroquine,amilityprine OD as well as hypothermia. Knowing this will give you a better understanding of why these methods lead to death and how you can improve upon them when you are to carry it out. On an EKG, the QT interval represents the summation of action potentials in cardiac muscle cells, which can be caused by an increase in inward current through sodium or calcium channels, or a decrease in outward current through potassium channels. QT prolongation is an established side effect of anti-arrhythmic medicines, but can also be caused by a wide range of non-cardiac medicines, including antibiotics, antihistamines, opioid analgesics and complementary medicines. Chloroquine qt prolongation Chloroquine Oral Uses, Side Effects, Interactions, Pictures, Warnings., Chloroquine Phosphate 500mg Tablets - HealthWarehouse Plaquenil side effects insomniaLupus like illness normal blood work plaquenil effective A table showing the common drugs which may cause QT prolongation. Pathophysiology. Congenital long QT syndrome may be caused by an imbalance of the sympathetic innervation in the heart especially the stellate ganglion or derangements in the cardiac ion flow, resulting in prolongation of the action potential. Long QT Syndrome LQTS. Inducing QT Prolongation and Sudden Death Sanctioned Suicide. Drugs and the QT Interval – What Do Pharmacists Need to Know?. Blockade of cardiac potassium channels leads to delayed ventricular repolarization and QT prolongation. Redistribution of potassium intracellularly can cause hypokalaemia. Features. After overdose, chloroquine is rapidly absorbed, with peak concentrations achieved within 1–3 hours. Drug-induced QT interval prolongation Experience with both QT/QTc interval-prolonging medicines and the congenital long QT syndrome suggests • A QT/QTc interval 500ms is associated with a higher risk of TdP and sudden cardiac death; • Among drugs with QT/QTc interval-prolonging potential, Chloroquine is associated with an increased risk of QT prolongation and torsade de pointes TdP; fatalities have been reported. The risk of QT prolongation is increased with higher chloroquine doses. QT prolongation has occurred during therapeutic use of atomoxetine and following overdose.