The most commonly used DMARD is methotrexate (Trexall®, Rheumatrex®, Otrexup®, Resuvo®). Other DMARDs include sulfasalazine (Azulfidine®), leflunomide (Arava®), hydroxychloroquine (Plaquenil®), Cyclosporine (Neoral®, Sandimmune®), Azathioprine (Imuran®), and Apremilast (Otezla®). What does plaquenil help Plaquenil costfor generic Leflunomide is the generic form of the brand-name medicine Arava, which is used to treat rheumatoid arthritis a condition in which the body attacks its own joints. This prescription medication. The study is based on leflunomide and hydroxychloroquine sulfate the active ingredients of Arava and Plaquenil, respectively, and Arava and Plaquenil the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Fuerst and co-workers noted the risk of postoperative wound healing complications in patients undergoing leflunomide therapy was significantly higher than in patients undergoing alternative treatments with methotrexate.17 These authors reported a 40.6 percent complication rate in patients undergoing leflunomide therapy in comparison to a 13.6. This prevents some cells in your body from reproducing themselves. Methotrexate works by blocking enzymes that help DNA (genetic material in the cells of your body) form or repair. Leflunomide methotrexate and hydroxychloroquine Anyone on Leflunomide, Hydroxychloroquine and MTX? - NRAS, Arava and Plaquenil drug interactions - eHealthMe Plaquenil maculopathy rateChloroquine eye exam for macular lesions The U. S. Food and Drug Administration FDA is adding information on severe liver injury to the Boxed Warning of Arava leflunomide – a drug used to treat rheumatoid arthritis - to. FDA Drug Safety Communication New boxed warning for severe liver.. A Guide To Perioperative Management Of The Rheumatoid Patient.. Anyone used plaquenil and arava which is better? DailyStrength. Traditional DMARDs Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies Amy C. Cannella, James R. O’dell Key Points Methotrexate is one of the most durable and frequently used disease-modifying antirheumatic drugs DMARDs in monotherapy as well as the cornerstone of combination therapy for rheumatoid. Among those who were on leflunomide, four were on a single drug while one also received methotrexate. Both patients in the other group were on methotrexate and hydroxychloroquine. The onset of neuropathy was on an average 3 months range 45 days to 120 days after the initiation of leflunomide. CHICAGO – Combination therapy with leflunomide and hydroxychloroquine met all goals for efficacy, safety, and tolerability among patients with primary Sjögren’s syndrome in a randomized, placebo-controlled pilot study, lending support to evidence suggesting the two drugs have additive benefits.