Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine powder Chloroquine and proguanil does it work afectively as anti malarial Kelley, Hi. Some people DO get an allergic rash from hydroxychloroquine = the generic form. I've read that fewer get it from Plaquenil = the name brand, so some rheumies presecribe it even though it's more expensive. Does the printout you got with your Rx mention the rash possibility? Have you spoken with your rheumie? I am on all sorts of meds including MTX and Hydroxy. I have recently developed an itchy rash which only affects my cheeks and eyebrows and haven't a clue what's causing it, so I hope you get some helpful replies that might help me too! I can't face the GP again, as I am sure I am one of the "heart-sink" patients! See your general practitioner when you can, and contact the rheumatologist, also when you can. They're hard to get sometimes. But unfortunately they're not miracle workers. However, stick with the Plaquenil if you can, as it is slow working, and you may yet have good results. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can you get a rash from plaquenil Plaquenil hydroxychloroquine 200mg is it causing itchy skin., Rash from Methotrexate or Hydroxychloroquine? - NRAS Aralen 250 mgStatistics plaquenil maculopathy Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Coming Off Plaquenil questions - Sclero Forums MAIN.. Rheumatoid Arthritis Medication Beware of Sunburn if You.. A more severe rash affecting larger areas of the body may occur but is not common. If this type of rash occurs, other medications such as anti-histamines and steroids may be required to help with symptoms. Over time, hydroxychloroquine may uncommonly have an adverse effect on the retina that can lead to permanent visual damage if not picked up. I have been on plaquenil for about 3 weeks and I am starting to get a itchy rash. It's pretty mild so far starting on my forearms and now on my chest a little and the rest of my arms. Has anyone else had this problem? Will it go away? I am going to call my doc tomorrow but just wanted someone's opinion. Thank you Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you.