Prophylaxis for chloroquine resistant malaria

Discussion in 'Hydroxychloroquine 200mg' started by doni, 05-Mar-2020.

  1. Aleksey_Tim Well-Known Member

    Prophylaxis for chloroquine resistant malaria


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    For travel to areas where chloroquine resistance is present, mefloquine is the only medication recommended for malaria prophylaxis during pregnancy. Studies of mefloquine use during pregnancy have found no indication of adverse effects on the fetus. Experts are evaluating the safety of atovaquone-proguanil use during pregnancy. In areas where there is chloroquine-resistant malaria, either atovaquone/proguanil Malarone, mefloquine Lariam or doxycycline can be used for prophylaxis. Primaquine is a good alternative, but requires a G-6-PD screening blood test. High prevalence of chloroquine-resistant P. vivax confirmed in Papua New Guinea and Indonesia; 115 143 also reported in Burma Myanmar, India, and Central and South America. 143. Do not use for prevention of malaria in individuals traveling to malarious areas where chloroquine-resistant P. falciparum or chloroquine-resistant P. vivax malaria.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Prophylaxis for chloroquine resistant malaria

    Chloroquine-Resistant Malaria –, Malaria Travel & Health Guide, 2019 Online Book

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  6. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus. Chloroquine is not associated with serum enzyme elevations and is an extremely rare cause of clinically apparent acute liver injury.

    • Chloroquine - LiverTox - NCBI Bookshelf.
    • Plaquenil Monograph for Professionals -.
    • Malaria Information and Prophylaxis, by Country S - CDC.

    Considerations when choosing a drug for malaria prophylaxis Recommendations for drugs to prevent malaria differ by country of travel and can be found in Malaria Information by Country. Recommended drugs for each country are listed in alphabetical order and have comparable efficacy in that country. Apr 15, 2002 Chloroquine is the drug of choice for people who travel to these areas; however, resistance to chloroquine is now widespread in all areas of the world where malaria is endemic, but it is still an. Chloroquine, an old malaria drug, may help treat novel coronavirus, doctors say Chloroquine, or hydroxychloroquine, has been used to treat malaria since 1944.

     
  7. Scorb Moderator

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Immune & Autoimmune - Lupus Plaquenil - when to take the. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects Hydroxychloroquine Oral Uses, Side Effects, Interactions.
     
  8. akininsp Guest

    Haemozoin is a disposal product formed from the digestion of blood by some blood-feeding parasites. Hemozoin production by Plasmodium falciparum variation with. Malarial hemozoin from target to tool. Semantic Scholar Hemozoin production by Plasmodium falciparum variation.
     
  9. SAPE Moderator

    Chloroquine and/or Proguanil - Fit for Travel Chloroquine and/or Proguanil A - Be Aware When There is a Risk However Small. Find out if there is a malaria risk in the area you are visiting. Aspects of travel may increase the risk e.g. rural travel, rainy season or unscreened accommodation.

    CHLOROQUINE Drug BNF content published by NICE
     
  10. yurist Moderator

    Levofloxacin - Wikipedia Levofloxacin, sold under the trade names Levaquin among others, is an antibiotic. It is used to treat a number of bacterial infections including acute bacterial sinusitis, pneumonia, H. pylori in combination with other medications, urinary tract infections, chronic prostatitis, and some types of gastroenteritis.

    A Coronavirus Question Chloroquine After Fluoroquinolones.