Chloroquine cancer therapy

Discussion in 'Hydroxychloroquine Plaquenil' started by Lvovskiy, 22-Feb-2020.

  1. shiv1980 Moderator

    Chloroquine cancer therapy


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    AbstractBackgroundThe anti-malarial drug chloroquine has recently been discovered as a novel anti-tumor agent. This article is to review the recent development of chloroquine being used in cancer therapy. MethodsPubMed, ScienceDirect and ClinicalKey served as the major databases. Key words included ‘chloroquine’, ‘cancer’, and ‘autophagy’. This, and its promising preclinical results, make CQ an outstanding candidate for repurposing in cancer treatment. 1, 6, 18 The Repurposing Drugs in Oncology project that focuses on repurposing some well‐known and well‐characterized non‐cancer drugs for new uses in cancer treatment, has emphasized the importance of CQ and HCQ in. Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine cancer therapy

    Malaria drugs could help to combat cancer, Dissecting pharmacological effects of chloroquine in cancer.

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  3. This drug may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes this drug by accident, get medical help right away. If your child is pregnant Tell the doctor if your child is pregnant or becomes pregnant.

    • Chloroquine - Memorial Sloan Kettering Cancer Center.
    • Chloroquine and hydroxychloroquine for cancer therapy.
    • The utility of chloroquine in cancer therapy Current Medical..

    Strange as it may sound, but it is true. Yes, this is what a group of researchers from Harvard Medical School recently reported in a reputed journal. I believe most of us especially those living in India and Africa, are well aware of Chloroquine, which is known as one of the most widely and successfully used first generation anti-malarial drug. Chloroquine and Cancer Treatment . are well aware of Chloroquine, which is known as one of the most widely and successfully used first generation anti-malarial drug. It is very famous for its effectiveness rather infamous for its characteristic bitter taste, I still remember during my childhood back in India, elders used to threaten. Chloroquine has been used for many years to treat patients with malaria, lupus, and rheumatoid arthritis, but more recently, hydroxychloroquine has been evaluated as a treatment for pancreatic cancer, with encouraging preliminary results.

     
  4. lagif New Member

    Acquiring HCQ is easier than CQ in some areas, so I have done some research to find some literature on HCQ. Do either hydroxychol/Plaquenil put you at risk for greater. Stopping Plaquenil - General Discussion - Life With Lupus Plaquenil Indications, Side Effects, Warnings -
     
  5. Gorets XenForo Moderator

    Selected from data included with permission and copyrighted by First Databank, Inc. Prednisone and Plaquenil drug interactions - eHealthMe Plaquenil? I have been on prednisone for 15 months. Hydroxychloroquine MedlinePlus Drug Information
     
  6. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Ventricular arrhythmias and torsade de pointes have been reported in patients taking PLAQUENIL see OVERDOSAGE and DRUG INTERACTIONS. Ear and labyrinth disorders Vertigo, tinnitus, nystagmus, nerve deafness, deafness.

    Hydroxychloroquine Oral Route Before Using - Mayo Clinic