Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Hydroxychloroquine abuse Plaquenil and erosive osteoarthritis Plaquenil ful lfiel derg severe Hydroxychloroquine sulfate adverse effects Patient B shows a less severe stage of toxicity with small islands of retinal damage in the areas 5° to 15° from the fovea. CONCLUSION. Chloroquine or hydroxychloroquine can cause retinal dysfunction detectable using mfERG before toxicity is clinically apparent. Nov 01, 2015 H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Retinal toxicity associated with hydroxychloroquine and chloroquine Retinal Physician - Retinal Toxicities Caused by Systemic., Retinal Physician - Hydroxychloroquine Maculopathy An Update. Chloroquine torsadesChloroquine phosphate and prazi proSide effects of plaquenil 200 mg tabletsPlaquenil apsWhat is plaquenil toxicity Objective To report the detailed clinical findings of patients with retinal toxicity that developed secondary to the use of hydroxychloroquine sulfate n = 13, chloroquine phosphate n = 2, or a combination of the agents n = 1. Retinal Toxicity Associated With Hydroxychloroquine and.. Chloroquine retinopathy - Wikipedia. Recommendations on Screening for Chloroquine and.. Retinal toxicity associated with hydroxychloroquine and chloroquine risk factors, screening, and progression despite cessation of therapy. Arch Ophthalmol. 2011;. Use of microperimetry to evaluate hydroxychloroquine and chloroquine retinal toxicity. Can J Ophthalmol. The Risk of Retinal Toxicity with Plaquenil. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. Unfortunately, the retinal damage from these medications is largely irreversible, so it is critical to detect early retinal toxicity in the hopes of limiting the extent of visual loss.