Chloroquine mechanism of action ppt

Discussion in 'Hydroxychloroquine' started by, 18-Mar-2020.

  1. BlackD User

    Chloroquine mechanism of action ppt

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Mefloquine• Quinoline methanol derivative developed to deal with chloroquine resistant malaria• Rapidly acting erythrocytic schizonticide, slower than chloroquine & quinine• Effective against chloroquine sensitive & resistant plasmodia• Mechanism of action similar to chloroquine 32. Mechanism of action Chloroquine basic concentrates in parasite food vacuole acidic. Prevent heme polymerization into hemozoin causing heme accumulation toxic to parasite. Drug complex with heme disrupt cell membrane function. Other mechanism include intercalating of parasite DNA, DNA synthesis inhibition. 7. Effects of chloroquine? Chloroquine is a relatively well-tolerated. medicine. The most common adverse reactions reported are stomach pain, nausea, vomiting, and headache. These side effects can often be lessened by taking chloroquine with food. Chloroquine may also cause itching in some people. All medicines may have some side effects.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action ppt

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures., Chloroquine - SlideShare

  2. Plaquenil guidelines 2016
  3. It is a prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. PubChemThe mechanism of plasmodicidal action of chloroquine is not completely certain.

    • Chloroquine C18H26ClN3 - PubChem.
    • Medicines for the Prevention of Malaria While Traveling..
    • Antimalarial Drugs Modes of Action snd Mechanisms of Resistance.

    CHLOROQUINE MECHANISM OF ACTION At high conc it Inhibits synthesis of DNA and RNA in the plasmodium. As it is basic drug it Increases pH of the vacules in the parasite, so prevent its utilization of erythrocyte hemoglobin. OTHER USES Amebic liver abscess as chloroquine is concentrated in the liver. Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM Their mechanisms of action are unclear, though they appear to work by enhancing chloroquine uptake by the parasite. Interestingly, studies with verapamil suggest that, although it enhances chloroquine uptake in resistant strains, chloroquine levels still do not reach those found in sensitive strains.

  4. travelss User

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Mixed Connective Tissue Disease MCTD Explained. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil question Lupus Forums at The Lupus Site
  5. andrs New Member

    A variety of medications bind with the cellular lipids of the basal epithelial layer of the cornea due to their cationic, amphiphilic properties. Hydroxychloroquine Uses, Dosage & Side Effects - In vivo confocal microscopy in hydroxychloroquine-induced. Corneal verticillata - American Academy of Ophthalmology
  6. benon Guest

    Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings. Mark a calendar to help you remember. This drug is usually started 2 weeks before entering the area with malaria. Take it once weekly while in the area, and continue taking it for 4 to 8 weeks after leaving the area or as directed by your doctor. To treat malaria, follow your doctor's instructions.

    Protecting your eyesight when taking Plaquenil Lupus.