Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Plaquenil testing review of optometry Plaquenil and cataracts Does hydroxychloroquine affect immune system Plaquenil for sun allergy Group I displayed observable chloroquine fundus toxicity, Group II chronic chloroquine use with no observable fundus alterations, and Group III as a normal control group. On SD-OCT 87.5% of Group I showed peripapillary RNFL thinning in at least one quadrant whereas Groups II. Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine eye toxicity Hydroxychloroquine-Induced Retinal Toxicity - American., Retinal toxicity associated with chronic exposure to. Plaquenil dosage for sarcoidosis Apr 02, 2019 However, a very close eye needs to be kept on this child as life-threatening toxicity may evolve rapidly. It is prudent to intubate a patient with a potentially significant chloroquine overdose if there is any significant depression of consciousness level or cardiovascular instability. Chloroquine poisoning • LITFL • Clinical Case Tox Conundrum. Recommendations on Screening for Chloroquine and.. Chloroquine retinopathy - Wikipedia. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. By 2/2010 things were so dim I could not see to shop in stores. I quit taking Plaquenil but the DR still said no toxicity. My eyes continued to get worst. In tears I went back in July he finally sent me to a retina specialist. You don't have to have Bulls eye damage to have toxicity Over weight women over 60 should beware of taking Plaquenil. In view of the fact that all electron micro scopic studies on chloroquine toxicity in the eye have to date been limited to experimental animals, and because our experience has shown that tissues routinely fixed in Forma lin may occasionally be helpful in such stud ies,2 we decided to re-examine the material available from Wetterhold and Winter.