and other countries, cow's milk and plant-derived milk substitutes are fortified with vitamin D, as are many breakfast cereals. Dietary recommendations typically assume that all of a person's vitamin D is taken by mouth, as sun exposure in the population is variable and recommendations about the amount of sun exposure that is safe are uncertain in view of the skin cancer risk. What is the function of hydroxychloroquine sulfate tablets Plaquenil and weight gain forum Chloroquine cell toxicity Those with severe cases of systemic lupus erythematosus SLE have low levels of vitamin D, according to new research. The study, “ 25-Hydroxivitamin D Serum Concentration, Not Free and Bioavailable Vitamin D, Is Associated with Disease Activity in Systemic Lupus Erythematosus Patients,” was published in the journal PLoS One. A relationship between vitamin D deficiency and fatigue, but not with lupus activity or irreversible organ damage, was found. Thereafter, patients were treated with oral vitamin D 3 in the form of tablets containing fixed combinations of calcium and cholecalciferol or with calcidiol in liquid form at the discretion of the attending physician. Here, we report the case of two patients in whom conventional treatment was unsuccessful but who responded to hydroxychloroquine and high-dose vitamin D replacement therapy. To the best of our knowledge, this is the first description of successful treatment for immune thrombocytopenia with high-dose vitamin D and hydroxychloroquine. A protein enzyme must hydroxylate it to convert it to the active form. As vitamin D can be synthesized in adequate amounts by most mammals exposed to sufficient sunlight, it is not an essential dietary factor, although not technically a vitamin. Vitamin D from the diet, or from skin synthesis, is biologically inactive. Hydroxychloroquine with vit d Vitamin d and Hydroxychloroquine sulfate drug interactions - eHealthMe, Changes in vitamin D levels in patients with systemic lupus. Lexapro and plaquenil The study is based on hydroxychloroquine sulfate and ergocalciferol the active ingredients of Plaquenil and Vitamin d, respectively, and Plaquenil and Vitamin d the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Plaquenil and Vitamin d drug interactions - eHealthMe. Refractory immune thrombocytopenia successfully treated with high-dose.. Plaquenil Oral Interactions with Other Medication. I keep reading about the use of vitamin D with autoimmune diseases. How important is it for Sjögren’s patients? A. Vitamin D is important in bone and cartilage homeostasis. New evidence indicates that vitamin D may have extraskeletal benefits on several systems including the immune system. Vitamin D is primarily produced in the skin by the action of sunlight, and possibly patients receiving doxycycline-hydroxychloroquine treatment are not exposed to sunlight because of photosensitization and thus present vitamin D deficiency. We propose that patients with long-term doxycycline-and-hydroxychloroquine treatment should be regularly tested, and in cases of vitamin D deficiency, treatment with a vitamin D supplement should be added. The duration of treatment was also associated with the level of vitamin D P 0.0001, and control patients presented significantly higher vitamin D levels than patients receiving doxycycline-hydroxychloroquine, whether for less than or for more than 3 months P 0.0001 and P 0.0001, respectively Fig. 1b.