Why malaria becomes resistant to chloroquine

Discussion in 'Plaquenil Generic' started by valakh, 02-Mar-2020.

  1. anubisss New Member

    Why malaria becomes resistant to chloroquine


    Artemisinin Combination Therapies, or ACTs, are currently the frontline treatments against malaria. Although these treatments are working well in many parts of the world, there is serious concern that malaria parasites are once again developing widespread resistance to this vital treatment.

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    P. falciparum is now highly resistant to chloroquine in most malaria-affected areas. Resistance to SP is also widespread and has developed much more rapidly. Resistance to mefloquine is confined only to those areas where it has been used widely Thailand, Cambodia, and Vietnam but has arisen within six years of systematic deployment. Watching Resistance Unfold. In April, Wirth and other leaders of the Initiative reported on a powerful combination of genome search methods that enabled them to discover new resistance genes inPlasmodium falciparum, the malaria parasite. They even used one of these genes to convert a docile, easily killed parasite into a resistant one. Drug-resistant P. falciparum. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

    The cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. As the threat of antimalarial drug resistance grows, there is increasing pressure to sustain the efficacy of existing treatments, develop alternative treatments, as well putting in place preventative measures such as bednets.

    Why malaria becomes resistant to chloroquine

    Chloroquine Indications, Side Effects, Warnings -, Unlocking the secrets of drug resistance in malaria parasites

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  7. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

    • Chloroquine - Wikipedia.
    • CDC - Malaria - Malaria Worldwide - How Can Malaria Cases and Deaths Be..
    • Chloroquine MedlinePlus Drug Information.

    Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance. Do not use Chloroquine phosphate tablets for the treatment of complicated malaria high-grade parasitemia and/or complications e.g. cerebral malaria or acute renal failure. Do not use Chloroquine phosphate tablets for malaria prophylaxis in areas where Chloroquine resistance occurs, Resistance to Chloroquine phosphate tablets is widespread in P. falciparum, and is reported in P.vivax see WARNINGS. These different forms of malaria are each treated with different medications, depending on what is most effective and available; P. vivax, for example, can be treated with chloroquine, whereas in many places, P. falciparum has become resistant to this drug.

     
  8. alex-2004 New Member

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Photosensitivity A Side Effect of RA Medications Plaquenil Hydroxychloroquine - Side Effects, Dosage. Will you have Photosensitivity reaction with Plaquenil.
     
  9. ArMaster Guest

    ive put on 45 lbs since starting this medication back in October it is January now so that’s 10lbs a month. Hydroxychlor Anti-Inflammatories discussions Therapies. Hydroxychloroquine User Reviews for Rheumatoid Arthritis. RA and Hydroxychloroquine How Effective is it for Rheumatoid.
     
  10. NatashaPetrovna Well-Known Member

    Plaquenil hydroxychloroquine sulfate dose, indications. Galsulfase Minor Theoretically, there is a possible drug interaction between galsulfase and medications which may impact lysosomal efficacy. Both chloroquine and hydroxychloroquine are weak bases that accumulate in acidic lysosomes because of ion trapping.

    Plaquenil hydroxychloroquine sulfate dosing, indications.