Ocular side effects of chloroquine therapy

Discussion in 'Reliable Pharmacy' started by drunas, 27-Feb-2020.

  1. Autoreg New Member

    Ocular side effects of chloroquine therapy


    Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention.

    Plaquenil and ms Chloroquine phosphate 250 mg day Plaquenil tabletas

    Long-term therapy with chloroquine can lead to irreversible retinal damage and serious loss of visual acuity and visual field. Not only are the retinal changes irreversible but they may continue to progress after discontinuance of the drug. What are the ocular side effects and risks of chloroquine? Corneal deposits. Corneal deposits occur rapidly in 90% of patients on chloroquine. Retinal toxicity. Irreversible retinal toxicity, causing bilateral bull’s eye retinopathy. Screening recommendations. Every patient planning to take. Only two third of patients comply with therapy, and most non-adherence to therapy are in patients under 80 kilograms in weight, likely because of an increased incidence of side effects. Common, nonocular, side effects of chloroquine and hydroxychloroquine include pruritus, headaches, dizziness, and gastrointestinal upset.

    Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine.

    Ocular side effects of chloroquine therapy

    Ocular side effects of chloroquine treatment of rheumatoid., Chloroquine DermNet NZ

  2. Toxicity of hydroxychloroquine
  3. Initially retinal toxicity due to long-term use of chloroquine Aralen for malaria was reported in 1959 by Hobbs et al. 106 Currently, hydroxychloroquine sulphate Plaquenil is the quinoline agent of choice for the treatment of autoimmune diseases with a far lower incidence of adverse reactions. 107, 108 Hydroxychloroquine has been associated with many ocular toxic effects including keratopathy, ciliary body dysfunction, lens opacities, outer retinal damage, and pigmentary retinopathy.

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    Ocular side effects Hydroxychloroquine can cause irreversible retinal toxicity, resulting in bilateral bull’s eye retinopathy, but is regarded as less toxic to the retina than chloroquine and it does not cause the corneal deposits seen with chloroquine therapy. Chloroquine has also been tested in clinical trials as an antiretroviral agent against HIV and as a radiosensitizer and chemosensitizer for human cancer therapy. However, the side effects of Chloroquine, including ocular toxicities, limit its long-term use 2-4,6. Hydroxychloroquine is a well tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity. Within the eye, hydroxychloroquine negatively impacts the cornea, ciliary body, and retina.

     
  4. giropa Well-Known Member

    Retinopathy, hair loss, photosensitivity, tinnitus, myopathy (long-term therapy). PLAQUENIL hydroxychloroquine sulfate Label Hydroxychloroquine Side Effects, Dosage, Uses, and More Drug spotlight on hydroxychloroquine Lupus Foundation of.
     
  5. Dzen Moderator

    Plaquenil The major macular disease which we know more about is age-related macular degeneration ARMD for which the NIH has guideline to help protect the macula including oral supplements of lutein and zeaxanthin. It is not known whether this would benefit patients on HCQ or those with toxicity.

    Retinal toxicity associated with chronic exposure to.
     
  6. Olejka XenForo Moderator

    CHAPTER 8 SPECTROPHOTOMETRIC ASSAY OF CHLOROQUINE PHOSPHATE Pharmacopeia USP 3. BP describes non-aqueous titration with perchloric acid as titrant where the end point is located potentiometrically. USP describes a UV-spectrophotometric method, where the absorbance of CQP in HCl medium is measured at 343 nm.

    Nonaqueous_titration