Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Puckering of tongue plaquenil Plaquenil and valacyclovir Plaquenil antibiotic interactions Can sulfasalazine and plaquenil be taken together Hydroxychloroquine may interact with other medications Heart drug. Taking digoxin with hydroxychloroquine may increase the levels of digoxin in your body. Insulin and other diabetes drugs. Hydroxychloroquine and diabetes drugs all decrease your blood. Drugs that affect heart rhythm. Digoxin/Hydroxychloroquine Interactions. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Serious. These medicines may interact and cause very harmful effects. Learn about drug interactions between digoxin oral and hydroxychloroquine oral and use the RxList drug interaction checker to check drug combinations. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Drug interactions between hydroxychloroquine Plaquenil hydroxychloroquine sulfate dosing, indications., Interactions between Plaquenil Oral and hydroxychloroquine. Chloroquine off target effectsIs plaquenil a steroid Hydroxychloroquine is excreted both renally and hepatically. The amount of hydroxychloroquine excreted in the urine as unchanged drug ranges from 6% to 60% median 23%, and 17% is excreted in the urine as metabolized drug. Hydroxychloroquine Information for Providers AIDSinfo. Digoxin oral and hydroxychloroquine oral Drug Interactions.. Plaquenil and Doxycycline hyclate drug interactions.. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Other Interactions. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.