Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Malarone chloroquine resistance ncbi Patient teaching on hydroxychloroquine Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. An elderly woman being treated with hydroxychloroquine for systemic lupus erythematosus developed drug-associated black and blue pigmentation of her skin. The dyschromia was misinterpreted by her clinician as elder abuse and Adult Protective Services was notified. The family was eventually cleared of suspected elder abuse. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine pigmentation histology Hydroxychloroquine‐induced hyperpigmentation the staining pattern., Hydroxychloroquine MedlinePlus Drug Information What does plaquenil do for raHydroxychloroquine and seizure medsHydroxychloroquine long termIncidence of adverse affects to chloroquineChloroquine phosphate effects on fish The hydroxychloroquine was indicated for systemic lupus erythematosus in 73.2%, dermatomyositis in 12.2%, rheumatoid arthritis in 9.8%, actinic lichen and sarcoidosis each in 2.4%. Cutaneous pigmented lesions were found in 21 cases 51%, mucous pigmentation in 5 cases 12% and nail pigmentation in 1 case 2.5%. Hydroxychloroquine-induced hyperpigmentation in systemic.. Hydroxychloroquine-Associated Hyperpigmentation Mimicking.. Hydroxychloroquine-induced pigmentation in patients with.. Home August 2013 - Volume 19 - Issue 5 Hydroxychloroquine-Induced Hyperpigmentation. Log in to view full text. If you're not a subscriber, you can You can read the full text of this article if you-- Select an option -- Log In Buy This Article Become a Subscriber Home August 2013 - Volume 19 - Issue 5 Hydroxychloroquine-Induced Hyperpigmentation. Log in to view full text. If you're not a subscriber, you can Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ.