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Tamoxifen after double mastectomy

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    Tamoxifen after double mastectomy


    I was diagnosed with Extensive DCIS, estrogen receptor positive with a very small amount of microinvasion cancerous cells. I had a bilateral mastectomy and my medical oncologist has given me an option to take or not take tamoxifen. I am just trying to get some feedback so I can make the right decision. what is prednisone for I just had a unilateral mastectomy due to recent diagnosis for breast cancer (DCIS grade 3 with less than 1mm micro-invasion, 5 lymph nodes removed and tested negative, 0/5, BRAC 1 and 2 gene tested negative). The oncologist said I do not need chemo or radiation, but want me to take Tamoxifen for at least 5 years. Now I am very struggling on whether to take it or not. I really need other patients' help on deciding if I should take Tamoxifen or not. The only reason that I don't want to take the Tamoxifen is because I am scared about getting the possibility of having endometrial cancer, sometimes, my endometrial thickness is already a concern by the radiologist, thus I am desperately hoping to seek real-life experiences and advice from anyone here who has already gone through this. My questions are: If you have taken Tamoxifen for years, have you suffered from any significant side effects (particularly uterine or endometrial cancer)? Like you double masectomy on Tamoxifen three years because Estrogen Positive and pre menopausal. This is a new view as I think too many people get it back after five years in my opinion (as did my mum) and they appear to be trying to prolong it to that length of time. If you had opted not to take Tamoxifen years ago, do you still think it's a good decision or a decision you regret about now? BUT my oncologist is very proactive on keeping fit and eventually I could virtually not move and had to stop going to my beloved fun gym classes.

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    Cancer study Most don't need double mastectomy. of women who had a healthy breast removed after getting cancer diagnosed in the other one. Women can take tamoxifen or one of several newer drugs called aromatase. prednisone 30 mg for 5 days I have so much to say in this post I don’t even know where to start. I guess you could say this one is a bit of a rant. And that promise to work on being less wordy. Women with close relatives who've been diagnosed with breast cancer have a higher risk of developing the disease. If you've had one first-degree female relative.

    I have so much to say in this post I don’t even know where to start. And that promise to work on being less wordy – well, not today! I say if you don’t speak up, your doctor will just naturally assume (and rightfully so) that everything’s fine. As I mentioned in my previous post, the three FDA approved drugs most commonly prescribed for adjuvant hormonal therapy for post-menopausal early stage , HR-positive breast cancer patients are anastrozole (Arimidex®), letrozole (Femera®) and exemestane (Aromasin®). I’m a firm believer that a good rant now and then is a good thing, even a healthy thing, so that’s one reason I’m sharing about my experience with the dark side of aromatase inhibitors. If a whole bunch of us don’t speak up about whatever the issue might be, why should we expect things to ever change? It should also be noted that such drugs are also sometimes used for other purposes, such as treatment of metastatic breast cancer and even for prevention purposes. First of all, many women hesitate to talk about the nasty side effects of AIs because they don’t want to be perceived as complainers or whiners. AIs have been proven to be effective in preventing recurrence. This is a good thing and it’s important to take them and keep taking them if one has been prescribed for you and you are able to tolerate it. I am not suggesting and would never suggest that a woman do otherwise. The side effects of all three of these drugs are similar and include bone loss, weight gain, fatigue, hair loss, vaginal dryness, loss of libido, joint pain, insomnia and bone fractures to name a few. And of course, some of these same side effects also affect some women taking Tamoxifen. In the PALOMA-3 study, the combination of the CDK4 and CDK6 inhibitor palbociclib and fulvestrant was associated with significant improvements in progression-free survival compared with fulvestrant plus placebo in patients with metastatic breast cancer. Identification of patients most suitable for the addition of palbociclib to endocrine therapy after tumour recurrence is crucial for treatment optimisation in metastatic breast cancer. We aimed to confirm our earlier findings with this extended follow-up and show our results for subgroup and biomarker analyses. In this multicentre, double-blind, randomised phase 3 study, women aged 18 years or older with hormone-receptor-positive, HER2-negative metastatic breast cancer that had progressed on previous endocrine therapy were stratified by sensitivity to previous hormonal therapy, menopausal status, and presence of visceral metastasis at 144 centres in 17 countries. Eligible patients—ie, any menopausal status, Eastern Cooperative Oncology Group performance status 0–1, measurable disease or bone disease only, and disease relapse or progression after previous endocrine therapy for advanced disease during treatment or within 12 months of completion of adjuvant therapy—were randomly assigned (2:1) via a centralised interactive web-based and voice-based randomisation system to receive oral palbociclib (125 mg daily for 3 weeks followed by a week off over 28-day cycles) plus 500 mg fulvestrant (intramuscular injection on days 1 and 15 of cycle 1; then on day 1 of subsequent 28-day cycles) or placebo plus fulvestrant. The primary endpoint was investigator-assessed progression-free survival. We also assessed endocrine therapy resistance by clinical parameters, quantitative hormone-receptor expression, and tumour Between Oct 7, 2013, and Aug 26, 2014, 521 patients were randomly assigned, 347 to fulvestrant plus palbociclib and 174 to fulvestrant plus placebo. Study enrolment is closed and overall survival follow-up is in progress.

    Tamoxifen after double mastectomy

    Breast Cancer Prevention PDQ®—Health Professional Version -., The Dark Side of Aromatase Inhibitors – Part 2 Nancy's Point

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  6. Do Not Do Recommendation. Do not offer tamoxifen or raloxifene to women who were at high risk of breast cancer but have had a bilateral mastectomy.

    • Do not offer tamoxifen or raloxifene to women who were at high risk.
    • Breast Cancer Risk Factors Family History
    • Double mastectomy after DCIS? - jabh's Question - Cancer Support.

    Ann Surg Oncol. 2011 Feb;182459-62. doi 10.1245/s10434-010-1335-2. Epub 2010 Sep 22. Analyzing the risk of recurrence after mastectomy for DCIS a. best way to buy propecia ASCO’s growing roster of cutting-edge journals serves readers as the most credible, authoritative, peer-reviewed resources for significant clinical oncology. Types of Cancer. Breast Cancer – Everything you need to know about the causes, treatments, and prevention

     
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    50 mg PO q Day initially for 5 days If no ovulation, treatment can be repeated as early as 30 days after previous therapy Dosage can be increased to 100 mg only in patients who do not respond to first course Body as a whole: Fever, tinnitus, weakness Cardiovascular: Arrhythmia, chest pain, edema, hypertension, palpitation, phlebitis, pulmonary embolism, shortness of breath, tachycardia, thrombophlebitis Central nervous system: Migraine headache, paresthesia, seizure, stroke, syncope Dermatologic: Acne, allergic reaction, erythema, erythema multiforme, erythema nodosum, hypertrichosis, pruritus, urticaria Genitourinary: Endometriosis, ovarian cyst (ovarian enlargement or cysts could, as such, be complicated by adnexal torsion), ovarian hemorrhage, tubal pregnancy, uterine hemorrhage; reduced endometrial thickness Hepatic: Transaminases increased, hepatitis, pancreatitis Musculoskeletal: Arthralgia, back pain, myalgia Neoplasms: Liver (hepatic hemangiosarcoma, liver cell adenoma, hepatocellular carcinoma); breast (fibrocystic disease, breast carcinoma); endometrium (endometrial carcinoma); nervous system (astrocytoma, pituitary tumor, prolactinoma, neurofibromatosis, glioblastoma multiforme, brain abscess); ovary (luteoma of pregnancy, dermoid cyst of the ovary, ovarian carcinoma); trophoblastic (hydatiform mole, choriocarcinoma); miscellaneous (melanoma, myeloma, perianal cysts, renal cell carcinoma, Hodgkin’s lymphoma, tongue carcinoma, bladder carcinoma) Psychiatric: Anxiety, irritability, mood changes, psychosis Visual disorders: Abnormal accommodation, cataract, eye pain, macular edema, optic neuritis, photopsia, posterior vitreous detachment, retinal hemorrhage, retinal thrombosis, retinal vascular spasm, temporary or prolonged loss of vision, possibly irreversible Metabolism disorders: Hypertriglyceridemia Other: Leukocytosis, thyroid disorder Careful attention should be given to selection of candidates for therapy; pelvic examination is necessary prior to treatment and before each subsequent course Uterine fibroids, pituitary or ovarian failure may occur Risk of ovarian enlargement & ovarian hyperstimulation syndrome (OHSS); transient liver function test abnormalities suggestive of hepatic dysfunction, which may be accompanied by morphologic changes on liver biopsy, reported in association with OHSS, which is a medical event distinct from uncomplicated ovarian enlargement; death due to hypovolemic shock, hemoconcentration, or thromboembolism has occurred; if enlargement of ovary occurs, additional therapy should not be given until ovaries have returned to pretreatment size, and dosage or duration of next course should be reduced; ovarian enlargement and cyst formation associated with therapy usually regresses spontaneously within a few days or weeks after discontinuing treatment; potential benefit of subsequent therapy in these cases should exceed risk Potential for multiple births, especially at 100 mg dosage Risk of visual disturbance (like scotoma & photopsia); patients should be warned that visual symptoms may render activities such as driving a car or operating machinery more hazardous than usual, particularly under conditions of variable lighting; while etiology of visual symptoms is not yet understood, patients with any visual symptoms should discontinue treatment and have complete ophthalmological evaluation carried out promptly Cases of hypertriglyceridemia reported; preexisting or family history of hyperlipidemia and use of higher than recommended dose and/or longer duration of treatment are associated with risk of hypertriglyceridemia; periodic monitoring of plasma triglycerides is recommended in patients with preexisting or family history of hyperlipidemia; pretreatment screening of triglyceride levels is recommended in patients initiating therapy Cases of pancreatitis reported Prolonged use of clomiphene citrate tablets USP may increase risk of a borderline or invasive ovarian tumor Use in pregnant women is contraindicated, as treatment does not offer benefit in this population; to avoid inadvertent administration during early pregnancy, appropriate tests should be utilized during each treatment cycle to determine whether ovulation and/or pregnancy occurs; patients should be evaluated carefully to exclude ovarian enlargement or ovarian cyst formation between each treatment cycle; the next course of therapy should be delayed until these conditions have been excluded Available human data from epidemiologic studies do not show apparent cause and effect relationship between clomiphene citrate periconceptual exposure and an increased risk of overall birth defects, or any specific anomaly It is not known whether drug is excreted in human milk; because many drugs are excreted in human milk, caution should be exercised if drug is administered to a nursing woman; in some patients, therapy may reduce lactation Half-Life elimination: 5-7 days Onset: Within 5-10 days Peak plasma time 6.5 hours Bioavailability: Readily absorbed from GI tract Metabolism: Enterohepatically circulated Excretion: feces 37-51%; small amount in urine The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Clomid mechanism of action FEPshop cheap generic cialis india Clomid, Serophene clomiphene dosing, indications, interactions. Letrozole or clomiphene citrate as first line for.
     
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